2025 Paper HighlightsMarch 2025

• Assessing Chat GPT theoretical knowledge and prescriptive accuracy in bacterial infections

• Male-Partner Treatment to Prevent Recurrence of Bacterial Vaginosis (link)

• Oral Switch Antibiotic Therapy in Uncomplicated Enterococcus Faecalis Bloodstream Infection (link)

• Oral Gepotidacin vs. Nitrofurantoin in Patients with Uncomplicated Urinary Tract Infection: EAGLE-2 and EAGLE-3 Trials (link)

Feb 2025

• CAMERA-2 Trial Post-Hoc Analysis: Association of daily body temperature, WBC count and CRP with mortality and persistent bacteremia in patients with Staphylococcus Aureus bacteremia. (link)

• Carbapenem combination therapy versus standard of care for persistent methicillin-susceptible Staphylococcus aureus bacteraemia. (link)

​Jan 2025

• Effectiveness of ceftazidime-avibactam versus ceftolozane-tazobactam for multidrug-resistant Pseudomonas aeruginosa infections in the USA (CACTUS): a multicentre, retrospective, observational study (link)

• Antibiotic Treatment for 7 versus 14 Days in Patients with Bloodstream Infections (link)

• Biomarker-Guided Antibiotic Duration for Hospitalized Patients With Suspected SepsisThe ADAPT-Sepsis Randomized Clinical Trial (link)

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2024 Paper Highlights
Oct 2024

• Efficacy of a Clinical Decision Rule to Enable Direct Oral Challenge in Patients With Low-Risk Penicillin Allergy (link)

• Exclusive oral antibiotic treatment for hospitalized community-acquired pneumonia: a post-hoc analysis of a randomized clinical trial (link)

 

​Sept 2024

• Timing of Influenza Antiviral Therapy and Risk of Death in Adults Hospitalized With Influenza-Associated Pneumonia, Influenza Hospitalization Surveillance Network (FluSurv-NET), 2012–2019 (link)

• Early Versus Late Antipseudomonal β-Lactam Antibiotic Dose Adjustment in Critically Ill Sepsis Patients With Acute Kidney Injury: A Prospective Observational Cohort Study (link)

• Short Versus Long Antibiotic Duration in Streptococcus pneumoniae Bacteremia (link)

• BLADDER score: evaluating a tool to support urinary diagnostic and antibiotic stewardship in hospitalized adults (link)

• Optimisation of empirical antimicrobial therapy in patients with hematological malignancies and febrile neutropenia (How Long study): an open label, randomised, controlled phase 4 trial. (link)

 

August 2024

• Lower Rates of Staphylococcus aureus Bloodstream Infection in Patients on Hemodialysis Receiving Trimethoprim-Sulfamethoxazole Melioidosis Prophylaxis (link)

• Adjunctive Single-Dose Liposomal Amphotericin to Prevent Cryptococcal Meningitis in People With Human Immunodeficiency Virus (HIV)–Associated Cryptococcal Antigenemia and Low Plasma Cryptococcal Antigen (CrAg) Titers (link)

• Clarithromycin for early anti-inflammatory responses in community acquired pneumonia in Greece (ACCESS): a randomised, double blind, placebo-controlled trial (link)

 

July 2024

• Efficacy and safety of an early oral switch in low-risk Staphylococcus aureus bloodstream infection (SABATO): an international, open-label, parallel-group, randomised, controlled, non-inferiority trial (SABATO Trial) (link)

• Trial of Short-Course Antimicrobial Therapy for Intraabdominal Infection (STOP-IT trial) (link )

• Continuous vs Intermittent Meropenem Administration in Critically Ill Patients With Sepsis - The MERCY Randomized Clinical Trial (Link)

 

June 2024​

• Preventing New Gram-negative Resistance Through Beta-Lactam Deescalation in Hospitalised Patients with Sepsis: A Retrospective Cohort Study (Link)

• Continuous vs Intermittent β-Lactam Antibiotic Infusions in Critically Ill Patients With Sepsis. The BLING III Randomized Clinical Trial (link)

• Long-term Oral Suppressive Antimicrobial Therapy in Infective Endocarditis (SATIE Study): An Observational Study (link)

• Anaerobic Antibiotic Coverage in Aspiration Pneumonia and the Associated Benefits and Harms: A Retrospective Cohort Study (link)

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May 2024

• Identifying Effective Durations of Antibiotic Therapy for the Treatment of Carbapenem-resistant Enterobacterales Bloodstream Infections: A Multicenter Observational Study (link)

• Early switch to oral antibiotic therapy in patients with low-risk neutropenic sepsis (EASI-SWITCH): a randomized non-inferiority trial (link) 

• Efficacy and safety of sulbactam-durlobactam versus colistin for the treatment of patients with serious infections caused by Acinetobacter baumannii-calcoaceticus complex: a multicentre, randomized, active-controlled, phase 3, non-inferiority clinical trial (ATTACK) (link)

• SOAB: Switch to Oral AntiBiotics in Gram-Negative Bacteraemia Trial (link)

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April 2024

• Impact of doxycycline on Clostridioides difficile infection in patients hospitalized with community-acquired pneumonia (link)

• Inappropriate Diagnosis of Pneumonia Among Hospitalized Adults (link)

• Five-Year Outcomes of the Partial Oral Treatment of Endocarditis (POET) Trial (link)

 

March 2024

• Efficacy and safety of a structured de-escalation from antipseudomonal β-lactams in bloodstream infections due to Enterobacterales (SIMPLIFY): an open-label, multicentre, randomized trial (link)

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Before 2024

• Impact of Enterococcus faecalis Endocarditis Treatment on Risk of Relapse (link)

• Treatment With Reduced-Dose Trimethoprim-Sulfamethoxazole Is Effective in Mild to Moderate Pneumocystis jirovecii Pneumonia in Patients With Hematologic Malignancies (link)

• Creation and Internal Validation of a Clinical Predictive Model for Fluconazole Resistance in Patients With Candida Bloodstream Infection (link)

• Oral Versus Standard Antimicrobial Treatment for Pyogenic Native Vertebral Osteomyelitis: A Single-Center, Retrospective, Propensity Score-Balanced Analysis (link)

• Persistent MRSA Bacteremia: Resetting the Clock for Optimal Management (link)

• Duration of Treatment for Pseudomonas aeruginosa bloodstream infection (BSI). A Retrospective Study (link)

• Antibiotic Overuse and Stewardship at Hospital Discharge: The Reducing Overuse of Antibiotics at Discharge Home Framework (link)

• Single-Dose Liposomal Amphotericin B Treatment for Cryptococcal Meningitis (link)

• Three Weeks Versus Six Weeks of Antibiotic Therapy for Diabetic Foot Osteomyelitis: A Prospective, Randomized, Noninferiority Pilot Trial (link)

• Antimicrobial stewardship in high-risk febrile neutropenic patients (link)

• The Incidence of Ocular Complications in Candidemic Patients and Implications for the Practice of Routine 
Eye Exams (link)

• Antibiotic Therapy for 6 or 12 Weeks for Prosthetic Joint Infection (link)

• Sign of the Times: Updating Infective Endocarditis Diagnostic Criteria to Recognize Enterococcus faecalis as a Typical Endocarditis Bacterium (link)

• Efficacy of Ceftazidime-avibactam Plus Aztreonam in Patients With Bloodstream Infections Caused by Metallo-β-lactamase–Producing Enterobacterales (link)

• Short-course aminoglycosides as adjunctive empirical therapy in patients with Gram-negative bloodstream infection , a cohort study (link)

• Comparative Effectiveness of Switching to Daptomycin  Versus Remaining on Vancomycin Among Patients With Methicillin-resistant Staphylococcus aureus Bloodstream Infections (link)

• Rifampin combination therapy in Staphylococcal prosthetic joint infections: a randomized controlled trial (link)

• Antibiotics versus no therapy in kidney transplant recipients with asymptomatic bacteriuria (ABU): a pragmatic, multicentre, randomised controlled trial (link)

• Outcomes of OPAT with Ceftriaxone for MSSA Blood Stream Infection (BSI)- A Single Center Observational Study (link)

• Switch from parenteral to oral antibiotics for brain abscesses: a retrospective cohort study of 109 patients (link)

• Piperacillin-Tazobactam Added to Vancomycin Increases Risk for AKI: Fact or Fiction? (link)

• Antimicrobial de-escalation in the critically ill patient and assessment of clinical cure: the DIANA study (link)

• Association Between Penicillin Allergy Documentation and Antibiotic Use (link)

• Efficacy of Early Oral Switch with β-Lactams for Low-Risk Staphylococcus aureus Bacteremia (link)

• Effect of CRP guided Antibiotic Treatment Duration vs. 7-Day Rx, or 14-Day Rx in Uncomplicated Gram-Negative Bacteraemia (link)

• Reappraisal of Linezolid Dosing in Renal Impairment to Improve Safety (link)

• Antibiotic treatment for 6 days versus 12 days in patients with severe cellulitis: a multicentre randomised, double-blind, placebo-controlled, non-inferiority trial (link)

• Pneumococcal Urinary Antigen Testing in United States Hospitals: A Missed Opportunity for Antimicrobial Stewardship (link)

• Four versus six weeks of antibiotic therapy for osteoarticular infections after implant removal: a randomized trial (link)

• Risk Factors and Outcomes Associated With Treatment of Asymptomatic Bacteriuria in Hospitalized Patients (link)

• Carbapenem-resistant Acinetobacter baumannii: in pursuit of an effective treatment (link)

• When not to start antibiotics: avoiding antibiotic overuse in the intensive care unit (link)

• Efficacy of Ceftriaxone 1 g daily Versus 2 g daily for The Treatment of Community-Acquired Pneumonia: A Systematic Review with Meta-Analysis (link)

• A viable approach for ‘low-risk’ patients labelled with penicillin allergy? (link)

• No Clinical Benefit to Treating Male Urinary Tract Infection Longer than Seven Days: An Outpatient Database Study (link)

• The Role of Ertapenem for the Treatment of Complicated Intra-abdominal Infections With a Positive Culture for Enterococcus faecalis (link)

• Cefazolin Versus Anti-Staphylococcal Penicillins for the Treatment of Patients with Methicillin-Susceptible Staphylococcus aureus Infection: A Meta-Analysis with Trial Sequential Analysis (link)

• Saturable elimination of piperacillin in critically ill patients: implications for continuous infusion (link)

• A Systematic Review of Single-Dose Aminoglycoside Therapy for Urinary Tract Infection: Is It Time To Resurrect an Old Strategy? (link)

• Utility of prior cultures in predicting antibiotic resistance of bloodstream infections due to Gram-negative pathogens: a multicentre observational cohort study (link)

• Catheter-related bloodstream infections with coagulase-negative Staphylococci: are antibiotics necessary if the catheter is removed? (link)

• You can't always get what you want, but if you try sometimes (with two tests—TST and IGRA—for tuberculosis) you get what you need (link)

• Fluoroquinolone-based versus beta lactam-based regimens for complicated intra-abdominal infections: a meta-analysis of randomized controlled trials (link)

• The dosing and monitoring of vancomycin: what is the best way forward? (link)

• Antibiotic allergy (Lancet)(link)

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